“It’s a preliminary, albeit great, first step towards thinking about developing a biomarker for risk in advance of our current ability to diagnose autism,” said Jason J. Wolff, lead author of the study.
The study may be useful for journalists writing new stories about autistic children and their parents; April is National Autism Awareness Month. It raises the possibility “that we may be able to interrupt that process with targeted intervention,” Wolff said.
Participants in the study, which was published online in the Advance section of the American Journal of Psychiatry, included 92 infants who have older siblings with autism and so were considered at high risk for developing the disorder. They were tested using a type of MRI at 6 months of age and had behavioral assessments done at 24 months. Most of the infants also had more brain-imaging scans at either or both 12 and 24 months of age, reports research-reporting service Newswise.
At 24 months, 28 infants — 30 percent — fell into the autism disorder spectrum, while 64 did not. “The two groups differed in white matter fiber tract development — pathways that connect brain regions — as measured by fractional anisotropy,” Newswise reports.
Based on the way water molecules move through brain issue, fractional anisotrophy measures the way white matter is organized and develops. In 12 of the 15 tracts of children who did develop autism, there were significant FA trajectories. “This evidence, which implicates multiple fiber pathways, suggests that autism is a whole-brain phenomenon not isolated to any particular brain region,” Wolff said. (Read more